History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children.

ABSTRACT:

Objective

HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammation and can be measured in the exhaled air. We investigated the relationship between exhaled nitric oxide (eNO), HIV status and airway abnormalities in perinatally HIV-infected children aged 6-19 years.

Design

A cross-sectional study.

Methods

HIV-infected individuals on antiretroviral therapy and HIV-uninfected children with no active tuberculosis (TB) or acute respiratory tract infection were recruited from a public hospital in Harare, Zimbabwe. Clinical history was collected and eNO testing and spirometry was performed. The association between eNO and explanatory variables (HIV, FEV1 z-score, CD4 cell count, viral load, history of

SUBMITTER: Sovershaeva E 

PROVIDER: S-EPMC6687035 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature