Functional Mixed-Effects Modeling of Longitudinal Duchenne Muscular Dystrophy Electrical Impedance Myography Data Using State-Space Approach.

ABSTRACT:

Objective

Electrical impedance myography (EIM) is a quantitative and objective tool to evaluate muscle status. EIM offers the possibility to replace conventional physical functioning scores or quality of life measures, which depend on patient cooperation and mood.

Methods

Here, we propose a functional mixed-effects model using a state-space approach to describe the response trajectories of EIM data measured on 16 boys with Duchenne muscular dystrophy and 12 healthy controls, both groups measured over a period of two years. The modeling framework presented imposes a smoothing spline structure on EIM data collected at each visit and taking into account of within subject correlations of these curves along the longitudinal measurements. The modeling framework is recast in a stat

SUBMITTER: Kapur K 

PROVIDER: S-EPMC6687059 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature