An episode level evaluation of the treatment journey of patients with major depressive disorder and treatment-resistant depression.

ABSTRACT:

Background

Many patients with major depressive disorder (MDD) fail to respond to antidepressant (AD) pharmacotherapy. The objectives of this study were to characterize MDD and treatment-resistant depression (TRD) at the level of pharmacologically treated episodes and to describe the sequential treatment patterns by lines of therapy (LOT) in the first two episodes.

Methods

Adults (≥18 years of age) with continuous enrollment ≥12 months before and after the first MDD diagnosis and treated with an AD, with or without an MDD-indicated antipsychotic (AP), were identified (1/1/2010-12/31/2015). The MDD episode started on the date of MDD diagnosis that was preceded by a clean period without any MDD diagnosis. The MDD episode ended on the last MDD diagnosis or the end of the days' s

SUBMITTER: Wu B 

PROVIDER: S-EPMC6687173 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature