Increased electroencephalography connectivity precedes epileptic spasm onset in infants with tuberous sclerosis complex.

ABSTRACT:

Objective

To identify whether abnormal electroencephalography (EEG) connectivity is present before the onset of epileptic spasms (ES) in infants with tuberous sclerosis complex (TSC).

Methods

Scalp EEG recordings were collected prospectively in infants diagnosed with TSC in the first year of life. This study compared the earliest recorded EEG from infants prior to ES onset (n = 16) and from infants who did not develop ES (n = 28). Five minutes of stage II or quiet sleep was clipped and filtered into canonical EEG frequency bands. Mutual information values between each pair of EEG channels were compared directly and used as a weighted graph to calculate graph measures of global efficiency, characteristic path length, average clustering coefficient, and modularity.

Results<

SUBMITTER: Davis PE 

PROVIDER: S-EPMC6687536 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature