Click and photo-release dual-functional nucleic acid nanostructures.

ABSTRACT: We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

SUBMITTER: Valsangkar VA 

PROVIDER: S-EPMC6687541 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature