Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population.

ABSTRACT:

Background

Polypeptide N-acetylgalactosaminyltransferase 16 (GALNT16) is an N-acetylgalactosaminyltransferase gene that alters protein O-glycosylation, which plays a role in tumor development. This study aims to explore the association of eight GALNT16 polymorphisms with susceptibility to breast cancer (BC).

Methods

This case-control study included 563 BC patients and 552 age-matched healthy controls from the Chinese Han population. The genotypes of GALNT16 polymorphisms were detected using the Agena MassARRAY. The relationship between GALNT16 polymorphisms and BC risk was evaluated using a chi-squared test with an odds ratio (OR) and 95% confidence intervals (CI) under five genetic models.

Results

We observed that rs2105269 and rs72625676 were associated with higher

SUBMITTER: Wu H 

PROVIDER: S-EPMC6687646 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature