Brain-behaviour modes of covariation in healthy and clinically depressed young people.

ABSTRACT: Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is a major challenge. This has particular relevance for mental health disorders where a failure to understand these links might hinder the development of better diagnostic approaches and therapeutics. Here, we investigated this question in 306 adolescents and young adults (14-24 y, 25 clinically depressed) using a multivariate statistical framework, based on canonical correlation analysis (CCA). By linking individual functional brain connectivity profiles to self-report questionnaires, IQ and demographic data we identified two distinct modes of covariation. The first mode mapped onto an externali

SUBMITTER: Mihalik A 

PROVIDER: S-EPMC6687746 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature