Vps28 Is Involved in the Intracellular Trafficking of Awd, the Drosophila Homolog of NME1/2.

ABSTRACT: The Awd (abnormal wing discs) gene is the Drosophila homolog of human NME1 and NME2 metastasis suppressor genes. These genes play a key role in tumor progression. Extensive studies revealed that intracellular NME1/2 protein levels could be related to either favorable or poor prognosis depending on tissue context. More recently, extracellular activities of NME1/2 proteins have also been reported, including a tumor- promoting function. We used Drosophila as a genetic model to investigate the mechanism controlling intra- and extracellular levels of NME1/2. We examined the role of several components of the ESCRT (endosomal sorting complex required for transport) complex in controlling Awd trafficking. We show that the Vps28 component of the ESCRT-I com

SUBMITTER: Mezzofanti E 

PROVIDER: S-EPMC6687847 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature