Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head.

ABSTRACT:

Background

Alcohol-induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of RETN (resistin; OMIM: 605565) and LDLR (low density lipoprotein receptor; OMIM: 606945) polymorphisms on the risk of alcohol-induced ONFH in Chinese Han population.

Methods

A case-control study including 201 patients and 201 controls was designed. Seven single nucleotide polymorphisms (SNPs) in RETN gene and four SNPs in LDLR gene were genotyped using Agena MassARRAY platform. In allele model and genetic model, chi-square test and logistic regression were used to study the associations between these SNPs and ONFH susceptibility. In addition, the relationships between these SNPs, clinical phe

SUBMITTER: Liu C 

PROVIDER: S-EPMC6687866 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature