Leveraging Genetic Findings for Precision Medicine in Vasculitis.

ABSTRACT: Vasculitides are a heterogeneous group of low frequent disorders, mainly characterized by the inflammation of blood vessels that narrows or occlude the lumen and limits the blood flow, leading eventually to significant tissue and organ damage. These disorders are classified depending on the size of the affected blood vessels in large, medium, and small vessel vasculitis. Currently, it is known that these syndromes show a complex etiology in which both environmental and genetic factors play a major role in their development. So far, these conditions are not curable and the therapeutic approaches are mainly symptomatic. Moreover, a percentage of the patients do not adequately respond to standard treatments. Over the last years, numerous genetic studies have been carried out to identify susce

SUBMITTER: Acosta-Herrera M 

PROVIDER: S-EPMC6687877 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature