Retrieval of spatial representation on network level in hippocampal CA3 accompanied by overexpression and mixture of stored network patterns.

ABSTRACT: Retrieval of stored network activity pattern has been shown as a competitive transition from one attractor state to another, orchestrated by local theta oscillation. However, the fine nature of this process that is considered as substrate of memory recall is not clear. We found that hippocampal network recall is characterized by hyperactivity in the CA3 place cell population, associated with an "overexpression" of the retrieved network pattern. The overexpression was based on recruitment of cells from the same (recalled) spatial representation with low expected firing probability at the given position. We propose that increased place cell activation during state transitions might facilitate pattern completion towards the retrieved network state and stabilize its expression in the network.

SUBMITTER: Zitricky F 

PROVIDER: S-EPMC6687893 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature