MiR-30b-5p acts as a tumor suppressor microRNA in esophageal squamous cell carcinoma.

ABSTRACT:

Background

To study miR-30b-5p expression in esophageal squamous cell carcinoma (ESCC) by comparisons between tumor tissues and matched adjacent non-cancerous tissues to elucidate the correlation between miR-30b-5p expression and ESCC clinical parameters, and to explore the signaling pathways associated with miR-30b-5p and key target genes.

Methods

Clinical data, cancer tissues, and adjacent non-cancerous tissues of 32 patients diagnosed with ESCC were collected from Taizhou Hospital of Zhejiang Province. The expression levels of miR-30b-5p were determined by real-time polymerase chain reaction (RT-PCR). mRNA data for ESCC tissues and normal tissues, and clinical materials of patients with ESCC were obtained from the Gene Expression Omnibus (GEO) database and The Cancer Geno

SUBMITTER: Xu J 

PROVIDER: S-EPMC6687993 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature