What Is the Value of Different Zika Vaccination Strategies to Prevent and Mitigate Zika Outbreaks?

ABSTRACT:

Background

While the 2015-2016 Zika epidemics prompted accelerated vaccine development, decision makers need to know the potential economic value of vaccination strategies.

Methods

We developed models of Honduras, Brazil, and Puerto Rico, simulated targeting different populations for Zika vaccination (women of childbearing age, school-aged children, young adults, and everyone) and then introduced various Zika outbreaks. Sensitivity analyses varied vaccine characteristics.

Results

With a 2% attack rate ($5 vaccination), compared to no vaccination, vaccinating women of childbearing age cost $314-$1664 per case averted ($790-$4221/disability-adjusted life-year [DALY] averted) in Honduras, and saved $847-$1644/case averted in Brazil, and $3648-$4177/case averted in Puerto

SUBMITTER: Bartsch SM 

PROVIDER: S-EPMC6688058 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature