Dimethyl fumarate abrogates dust mite-induced allergic asthma by altering dendritic cell function.

ABSTRACT:

Introduction

Allergic asthma is the most common inflammatory disease of upper airways. Airway dendritic cells (DCs) are key antigen presenting cells that regulate T helper 2 (Th2)-dependent allergic inflammation. Recent studies have shown critical role of airway DCs in the induction of Th2-mediated allergic inflammation and are attractive therapeutic targets in asthma. However, molecular signaling mechanism that regulate DCs function to Th2 immune responses are poorly understood. Here we aim to evaluate the immunomodulatory effect of dimethyl fumarate (DMF), an FDA approved small molecule drug, in the house dust mite (HDM)-induced experimental model of allergic asthma.

Methods

DMF was administered intranasally in the challenge period of HDM-induced murine model of experiment

SUBMITTER: Jaiswal AK 

PROVIDER: S-EPMC6688084 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature