Microfibrillar-associated protein 4 in serum is associated with asthma in Danish adolescents and young adults.

ABSTRACT:

Background

Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen-related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of asthma in vivo and proasthmatic pathways of bronchial smooth muscle cells in vitro. The aim of this study was to investigate the significance of serum MFAP4 in adolescents and young adolescents with persistent asthma.

Methods

Prospective, observational study including adolescents and young adults (age 11-27 years) previously diagnosed with asthma during childhood 2003 to 2005 (0-15 years) at the four pediatric outpatient clinics in the Region of Southern Denmark (n = 449). Healthy controls

SUBMITTER: Hoffmann-Petersen B 

PROVIDER: S-EPMC6688087 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature