Association between tumor necrosis factor-α and chronic obstructive pulmonary disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Patients diagnosed with chronic obstructive pulmonary disease (COPD) have increased risks for a series of physical and mental illnesses. Tumor necrosis factor-α (TNF-α) has been reported to participate in the development of COPD and its complications. However, the values of blood TNF-α level used in the diagnosis of COPD remains controversial. In view of this, we performed a systematic review and meta-analysis to evaluate the correlation between TNF-α level and COPD.

Methods

We searched PubMed, Web of Science, Embase and CNKI up to May 2018. The selection criteria were set according to the PICOS framework. A random-effects model was then applied to evaluate the overall effect sizes by calculating standard mean difference (SMD) and its 95% confidence intervals (CIs

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6688146 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature