Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions.

ABSTRACT:

Purpose of review

Allergen-antibody complexes are extremely valuable in describing the detailed molecular features of epitopes. This review summarizes insights gained from recently published co-structures and what obstacles impede the acquisition of further data.

Recent findings

Structural epitope data helped define the epitopes of two anti-Fel d 1 antibodies undergoing phase I clinical trials, providing a greater level of detail than was possible through hydrogen-deuterium exchange protection studies. Separately, a human camelid-like antibody structure with lysozyme described several unique features in a long variable loop that interacted with the active site cleft of Gal d 4. Finally, a co-structure conclusively demonstrated that Phl p 7 could function as a superantigen an

SUBMITTER: Mueller GA 

PROVIDER: S-EPMC6688168 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature