Accurate ethnicity prediction from placental DNA methylation data.

ABSTRACT:

Background

The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches to address confounding by population stratification using DNAme data may not generalize to populations or tissues outside those in which they were developed. To aid future placental DNAme studies in assessing population stratification, we developed an ethnicity classifier, PlaNET (Placental DNAme Elastic Net Ethnicity Tool), using five cohorts with Infinium Human Methylation 450k BeadChip array (HM450k) data from placental samples that is also compatible with the newer EPIC platform.

Results

Data from 509 placental samples were used to develop PlaNET and show

SUBMITTER: Yuan V 

PROVIDER: S-EPMC6688210 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature