Eosinophilic esophagitis in children: doubts and future perspectives.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder and represents the leading cause of food impaction. The pathogenesis of EoE is the result of an interplay between genetic, environmental and host immune system factors. New therapeutic approaches for EoE have been proposed. In this manuscript we review the current evidence regarding EoE management in pediatric age, with a particular focus on new findings related to the efficacy and safety of monoclonal antibodies.

Main body

Conventional therapies have failed in treating some patients with EoE, which then requires aggressive procedures such as esophageal dilatation. The most effective available medical therapy for EoE is swallowed topic corticosteroids (fluticasone propionate and bude

SUBMITTER: Cavalli E 

PROVIDER: S-EPMC6688237 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature