Enhanced migration and adhesion of peripheral blood neutrophils from SAPHO patients revealed by RNA-Seq.

ABSTRACT:

Background

SAPHO syndrome is a rare disease characterized by inflammatory lesions on skin and bones. Diversified manifestation and inadequate understanding of etiology has limited its diagnosis and treatment. The co-occurrence of other immune-mediated diseases strongly suggests an involvement of autoimmunity in SAPHO syndrome. However, the role of the largest population of circulating immune cells, neutrophils, is still not well explored. In this study, we performed RNA sequencing to profile the mRNA expression of neutrophils purified from peripheral blood of SAPHO patients to identify key genes associated with SAPHO syndrome, trying to find new functional molecules or biomarkers for this rare disease.

Results

A total of 442 differentially expressed genes were identified (p 

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6688242 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature