Hepatitis C virus genotyping based on Core and NS5B regions in Cameroonian patients.

ABSTRACT:

Background

Current HCV treatments are genotype specific although potential pan-genotype treatments have recently been described. Therefore, genotyping is an essential tool for the therapeutic management of HCV infection and a variety of technologies have been developed for HCV genotypes determination. Sequences analysis of HCV sub-genomic regions is considered as gold standard and is widely used for HCV genotyping. Here, we compared HCV genotyping using core and NS5B regions in routine practice in HCV-positive Cameroonian patients.

Methods

All plasma samples received at Centre Pasteur of Cameroon (CPC) in 2016 for HCV genotyping were included. Viral loads were determined using the Abbott Real Time assay. Further, genotyping was based on the amplification and sequencing of co

SUBMITTER: Tagnouokam-Ngoupo PA 

PROVIDER: S-EPMC6688274 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature