FOXD1 mutations are related to repeated implantation failure, intra-uterine growth restriction and preeclampsia.

ABSTRACT:

Background

Human reproductive disorders consist of frequently occurring dysfunctions including a broad range of phenotypes affecting fertility and women's health during pregnancy. Several female-related diseases have been associated with hypofertility/infertility phenotypes, such as recurrent pregnancy loss (RPL). Other occurring diseases may be life-threatening for the mother and foetus, such as preeclampsia (PE) and intra-uterine growth restriction (IUGR). FOXD1 was defined as a major molecule involved in embryo implantation in mice and humans by regulating endometrial/placental genes. FOXD1 mutations in human species have been functionally linked to RPL's origin.

Methods

FOXD1 gene mutation screening, in 158 patients affected by PE, IUGR, RPL and repeated implantation fai

SUBMITTER: Quintero-Ronderos P 

PROVIDER: S-EPMC6688323 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature