Higher expression of calcineurin predicts poor prognosis in unique subtype of ovarian cancer.

ABSTRACT:

Background

The role of calcineurin/NFAT signaling in ovarian cancer has been unknown. NFAT was significantly overexpressed in ovarian cancer tissues and that overexpression of NFAT was significantly associated with metastasis and poor prognosis on clinical tissue level. To investigate whether NFAT upstream protein, calcineurin (CN), affects the prognosis in various histological subtype of ovarian cancer (OC).

Methods

The association between CN and clinical features was analyzed in 50 OC patients treated from 2007 to 2012. CN expression was examined using immunohistochemistry. We observed the association of CN expression with the prognosis in these patients.

Results

CN expression was significantly increased in later-stage tumor tissue of serous carcinoma compared with

SUBMITTER: Xin B 

PROVIDER: S-EPMC6688357 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature