Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation.

ABSTRACT: Further insight into humoral viral immunity after hematopoietic cell transplantation (HCT) could have potential impact on donor selection or monitoring of patients. Currently, estimation of humoral immune recovery is inferred from lymphocyte counts or immunoglobulin levels and does not address vulnerability to specific viral infections. We interrogated the viral antibody repertoire before and after HCT using a novel serosurvey (VirScan) that detects immunoglobulin G responses to 206 viruses. We performed VirScan on cryopreserved serum from pre-HCT and 30, 100, and 365 days after myeloablative HCT from 37 donor-recipient pairs. We applied ecologic metrics (α- and β-diversity) and evaluated predictors of metrics and changes over time. Donor age and donor/recipient cytomegalovirus (CMV) seros

SUBMITTER: Bender Ignacio RA 

PROVIDER: S-EPMC6688428 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature