Mutation Spectrum of Cancer-Associated Genes in Patients With Early Onset of Colorectal Cancer.

ABSTRACT: Background: Colorectal cancer (CRC) incidence is rising worldwide, as well as in the Republic of Kazakhstan, while its occurrence is also increasing in the younger population. Hereditary forms associated with the development of colon and rectal cancer and early-onset CRC have never been studied in the population of Kazakhstan. The aim of this research was to investigate the spectrum of CRC-related gene mutations to determine which mutations cause early onset of CRC in the Kazakhstan population. Methods: The study included 125 unrelated patients from Kazakhstan (range 17-50 years in age) with early onset CRC. Genomic DNA was obtained from peripheral blood of the patients. Next-generation sequencing was performed using the TruSightCancer Kit on the MiSeq platform. The Studio Va

SUBMITTER: Zhunussova G 

PROVIDER: S-EPMC6688539 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature