Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes.

ABSTRACT: A novel diiridium complex [(N^C^N)₂Ir(bis-N^C)Ir(N^C^N)₂Cl]PF₆ (N^C^N = 2-[3-tert-butyl-5-(pyridin-2-yl)phenyl]pyridine; bis-N^C = 3,6-bis(4-tert-butylphenyl)pyridazine) was designed, synthesised and characterised. The key feature of the complex is the bridging pyridazine ligand which brings two cyclometallated Ir(iii) metal centres close together so that Cl also acts as a bridging ligand leading to a cationic complex. The ionic nature of the complex offers a possibility of improving solubility in water. The complex displays broad emission in the red region (λ _em = 520-720 nm, τ = 1.89 μs, Φ _em = 62% in degassed acetonitrile). Cellular assays by multiphoton (λ _ex = 800 nm) and confoc

SUBMITTER: Daniels RE 

PROVIDER: S-EPMC6688561 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature