Fetal growth and maternal glomerular filtration rate: a systematic review.

ABSTRACT:

Objective

Glomerular filtration rate (GFR) may influence concentrations of biomarkers of exposure and their etiologic significance in observational studies of associations between environmental contaminants and fetal growth. It is unknown whether the size of a developing fetus affects maternal GFR such that a small fetus leads to reduced plasma volume expansion (PVE), reduced GFR and subsequent higher concentrations of biomarkers in maternal serum. Our objective was to answer the question: "Is there an association between fetal growth and maternal GFR in humans?"

Methods

We adapted and applied the Navigation Guide systematic review methodology to assess the evidence of an association between fetal growth and GFR, either directly or indirectly via reduction in PVE.

Results

SUBMITTER: Vesterinen HM 

PROVIDER: S-EPMC6688630 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature