Neuroradiological Changes Following Single or Repetitive Mild TBI.

ABSTRACT:

Objectives

To test the hypothesis that there are differences in neuroradiological measures between single and repeated mild traumatic brain injury using multimodal MRI.

Methods

A closed-head momentum exchange model was used to produce one or three mild head injuries in young adult male rats compared to non-injured, age and weight-matched controls. Six-seven weeks post-injury, rats were studied for deficits in cognitive and motor function. Seven-eight weeks post-injury changes in brain anatomy and function were evaluated through analysis of high resolution T2 weighted images, resting-state BOLD functional connectivity, and diffusion weighted imaging with quantitative anisotropy.

Results

Head injuries occurred without skull fracture or signs of intracranial bleeding or

SUBMITTER: Kulkarni P 

PROVIDER: S-EPMC6688741 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature