Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.

ABSTRACT: Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research, seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) when the goal is to measure effects of novel therapeutic interventions on time to viral load rebound or altered viral setpoint. Trials with ATIs also intend to determine host, virological, and immunological markers that are predictive of sustained viral control off ART. Although ATI is increasingly incorporated into proof-of-concept trials, no consensus has been reached on strategies to maximise its utility and minimise its risks. In addition, differences in ATI trial designs hinder the ability to compare efficacy and safety of interventions across trials. Therefore, we held a meeting of stakeholders fr

SUBMITTER: Julg B 

PROVIDER: S-EPMC6688772 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature