"Associated" or "Secondary" IgA nephropathy? An outcome analysis.

ABSTRACT:

Background

Whether differences in outcome between primary (pIgAN) and secondary IgA nephropathy (sIgAN) exist is uncertain.

Methods

We conducted a retrospective, observational study that included all histologically diagnosed IgAN patients between 2010-2017 (N = 306), 248 with pIgAN and 58 with sIgAN. To obtain samples with similar risk of progression, sIgAN patients were grouped as liver disease and autoimmune/viral disease and propensity score matched to corresponding pIgAN samples. Univariate (Kaplan Meier) and multivariate time-dependent (Cox modelling) analyses were performed to identify predictors of the composite end-point (doubling of serum creatinine, end-stage kidney disease or death).

Results

Of the whole cohort, 20% had sIgAN (6% alcoholic cirrhosis, 6% aut

SUBMITTER: Obrisca B 

PROVIDER: S-EPMC6688810 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature