Can novel early non-invasive biomarkers of embryo quality be identified with time-lapse imaging to predict live birth?

ABSTRACT:

Study question

Can time-lapse imaging systems make it possible to identify novel early non-invasive biomarkers to predict live birth?

Summary answer

From mostly high-grade embryos, out of 35 morphometric, morphologic and morphokinetic variables, only pronuclei (PN) position at time of PN juxtaposition and the absence of multinucleated blastomeres at the 2-cell stage (MNB2cell), were potentially associated with live birth.

What is known already

Previous studies indicate that some kinetic markers may be predictive of blastocyst development and embryonic implantation. Certain teams have suggested including some of them in decisional algorithms for embryo transfers.

Study design, size, duration

Using a time-lapse incubator (EmbryoScope, Unisense FertiliTech), we re

SUBMITTER: Barberet J 

PROVIDER: S-EPMC6688874 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature