In vivo serial MRI of age-dependent neural progenitor cell migration in the rat brain.

ABSTRACT: The subventricular zone (SVZ) is a neurogenic niche in the mammalian brain, giving rise to migratory neural progenitor cells (NPC). In rodents, it is well-established that neurogenesis decreases with aging. MRI-based cell tracking has been used to measure various aspects of neurogenesis and NPC migration in rodents, yet it has not yet been validated in the context of age-related decrease in neurogenesis. This validation is critical to using these MRI techniques to study changes in neurogenesis that arise in diseases prevalent in aging populations and their combination with advanced cellular therapeutic approaches aiming to combat neurodegeneration. As such, in this work we used MRI-based cell tracking to measure endogenous neurogenesis and cell migration from the SVZ along the rostral migr

SUBMITTER: Shuboni-Mulligan DD 

PROVIDER: S-EPMC6688911 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature