Ontology highlight
ABSTRACT:
SUBMITTER: Shattuck JE
PROVIDER: S-EPMC6688984 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Shattuck Jenifer E JE Paul Kacy R KR Cascarina Sean M SM Ross Eric D ED
Nature communications 20190809 1
Stress granules are membraneless protein- and mRNA-rich organelles that form in response to perturbations in environmental conditions. Stress granule formation is reversible, and persistent stress granules have been implicated in a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis. However, characterization of the factors involved in dissolving stress granules is incomplete. Many stress granule proteins contain prion-like domains (PrLDs), some of which have been lin ...[more]