Fast and selective organocatalytic ring-opening polymerization by fluorinated alcohol without a cocatalyst.

ABSTRACT: Organocatalysis is an important branch of catalysis for various organic transformations and materials preparation. Polymerizations promoted by organic catalysts can produce polymeric materials without any metallic residues, providing charming materials for high-value and sensitive domains such as biomedical applications, microelectronic devices and food packaging. Herein, we describe a fluorinated alcohol based catalytic system for polypeptide synthesis via catalytic ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydride (NCA), fulfilling cocatalyst free, metal free, high rate and high selectivity. During polymerization, the fluorinated alcohol catalyst forms multiple dynamic hydrogen bonds with the initiator, monomer and propagating polymer chain. These cooperative hydrogen

SUBMITTER: Zhao W 

PROVIDER: S-EPMC6689068 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature