Transition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis.

ABSTRACT: Catalytic difunctionalization of alkenes has been an ideal strategy to generate structurally complex molecules with diverse substitution patterns. Although both phosphonyl and carboxyl groups are valuable functional groups, the simultaneous incorporation of them via catalytic difunctionalization of alkenes, ideally from abundant, inexpensive and easy-to-handle raw materials, has not been realized. Herein, we report the phosphonocarboxylation of alkenes with CO₂ via visible-light photoredox catalysis. This strategy is sustainable, general and practical, providing facile access to important β-phosphono carboxylic acids, including structurally complex unnatural α-amino acids. Diverse alkenes, including enamides, styrenes, enolsilanes and acrylates, undergo such reactions efficientl

SUBMITTER: Fu Q 

PROVIDER: S-EPMC6689110 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature