The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen.

ABSTRACT:

Background

Scavenger receptors play a significant role in clearing aged proteins from the plasma, including the large glycoprotein coagulation factors von Willebrand factor (VWF) and factor VIII (FVIII). A large genome-wide association study meta-analysis has identified genetic variants in the gene SCARA5, which encodes the class A scavenger receptor SCARA5, as being associated with plasma levels of VWF and FVIII.

Objectives

The ability of SCARA5 to regulate the clearance of VWF-FVIII was characterized.

Methods

VWF-FVIII interactions with SCARA5 were evaluated by solid phase binding assays and in vitro cell based assays. The influence of SCARA5 deficiency on VWF:Ag and half-life was assessed in a murine model. The expression pattern of SCARA5 and its colocalization wi

SUBMITTER: Swystun LL 

PROVIDER: S-EPMC6689151 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature