Long-term exposure to air pollution and hospitalization for dementia in the Rome longitudinal study.

ABSTRACT:

Background

Few studies have explored the role of air pollution in neurodegenerative processes, especially various types of dementia. Our aim was to evaluate the association between long-term exposure to air pollution and first hospitalization for dementia subtypes in a large administrative cohort.

Methods

We selected 350,844 subjects (free of dementia) aged 65-100 years at inclusion (21/10/2001) and followed them until 31/12/2013. We selected all subjects hospitalized for the first time with primary or secondary diagnoses of various forms of dementia. We estimated the exposure at residence using land use regression models for nitrogen oxides (NOx, NO₂) and particulate matter (PM) and a chemical transport model for ozone (O₃). We used Cox models to estim

SUBMITTER: Cerza F 

PROVIDER: S-EPMC6689157 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature