Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes.

ABSTRACT:

Background

General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements include mRNA folding, upstream open reading frames, specific nucleotides flanking the initiating AUG codon, protein coding sequence length, and codon usage. The quantitative contributions of these sequence features and how and why they coordinate to control translation rates are not well understood.

Results

Here, we show that these sequence features specify 42-81% of the variance in translation rates in Saccharomyces cerevisiae, Schizosaccharomyces pombe, Arabidopsis thaliana, Mus musculus, and Homo sapiens. We establish that control by RNA secondary s

SUBMITTER: Li JJ 

PROVIDER: S-EPMC6689182 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature