Brain Gene Expression in a Novel Mouse Model of Postpartum Mood Disorder.

ABSTRACT:

Background

Steroid sulfatase (STS) cleaves sulfate groups from steroid hormones; its expression/activity increases in late pregnancy and into the postpartum period. STS-deficient human and mouse mothers display elevated psychopathology and abnormal behaviour respectively; in mice, these effects can be partially normalised by antipsychotic (ziprasidone) administration.

Methodology

We compared brain gene expression in new mouse mothers administered the STS inhibitor 667-Coumate, or vehicle; significant changes were followed-up with pathway analysis and quantitative polymerase chain reaction (qPCR). Finally, the effects of combined 667-Coumate and ziprasidone administration on expression of the most robustly differentially-expressed genes were examined.

Results

Surprisin

SUBMITTER: Humby T 

PROVIDER: S-EPMC6689211 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature