Neuroplasticity transcript profile of the ventral striatum in the extinction of opioid-induced conditioned place preference.

ABSTRACT: Persistent drug-seeking behavior has been associated with deficits in neural circuits that regulate the extinction of addictive behaviors. Although there is extensive data that associates addiction phases with neuroplasticity changes in the reward circuit, little is known about the underlying mechanisms of extinction learning of opioid associated cues. Here, we combined morphine-conditioned place preference (CPP) with real-time polymerase chain reaction (RT-PCR) to identify the effects of extinction training on the expression of genes (mRNAs) associated with synaptic plasticity and opioid receptors in the ventral striatum/nucleus accumbens (VS/NAc). Following morphine extinction training, we identified two animal subgroups showing either extinction (low CPP) or extinction-resistance (high

SUBMITTER: Martinez-Rivera FJ 

PROVIDER: S-EPMC6689252 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature