Maternal allergen-specific IgG might protect the child against allergic sensitization.

ABSTRACT:

Background

Analysis of allergen-specific IgE responses in birth cohorts with microarrayed allergens has provided detailed information regarding the evolution of specific IgE responses in children. High-resolution data regarding early development of allergen-specific IgG are needed.

Objective

We sought to analyze IgG reactivity to microarrayed allergens in mothers during pregnancy, in cord blood samples, in breast milk, and in infants in the first years of life with the aim to investigate whether maternal allergen-specific IgG can protect against IgE sensitization in the offspring.

Methods

Plasma samples from mothers during the third trimester, cord blood, breast milk collected 2 months after delivery, and plasma samples from children at 6, 12, and 60 months of age wer

SUBMITTER: Lupinek C 

PROVIDER: S-EPMC6689269 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature