Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage.

ABSTRACT:

Purpose

Aim of the study was to find out if gallic acid (GA), a common phenolic in plant foods, prevents obesity induced DNA damage which plays a key role in the induction of overweight associated cancer.

Methods

Male and female C57BL6/J mice were fed with a low fat or a high fat diet (HFD). The HFD group received different doses GA (0, 2.6-20 mg/kg b.w./day) in the drinking water for 1 week. Subsequently, alterations of the genetic stability in blood and inner organs were monitored in single cell gel electrophoresis assays. To elucidate the underlying molecular mechanisms: oxidized DNA bases, alterations of the redox status, lipid and glucose metabolism, cytokine levels and hepatic NF-κB activity were monitored.

Results

HFD fed animals had higher body weights; increa

SUBMITTER: Setayesh T 

PROVIDER: S-EPMC6689278 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature