Association Between hsa-miR-30e Polymorphisms and Sporadic Primary Hyperparathyroidism Risk.

ABSTRACT:

Background/aim

Almost 15% of patients with sporadic primary hyperparathyroidism (sPHPT) present with multiple gland disease (MGD). The aim of this study was to investigate the potential role of two polymorphisms of the hsa-miR-30e, in sPHPT tumorigenesis.

Patients and methods

One-hundred twenty sPHPT patients, 77 presenting a single adenoma and 43 with MGD, and 54 healthy controls were genotyped. The SNPs were identified using the allele-specific PCR methodology, while the hsa-miR-30e expression was analyzed by real-time quantitative reverse transcriptase PCR.

Results

Hsa-miR-30e expression was found to be significantly higher in patients with MGD compared to patients with single adenomas (p=0.0019), but no differences were found regarding specific genotype carriers.

SUBMITTER: Mizamtsidi M 

PROVIDER: S-EPMC6689336 | biostudies-literature | 2019 Jul-Aug

REPOSITORIES: biostudies-literature