Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan.

ABSTRACT:

Background/aim

Recently, mounting evidence has shown that caspase-8 (CASP8) rs3834129 (-652, 6N insertion/deletion) polymorphism may serve as a genetic biomarker for personal risk of various cancer types. The contribution of CASP8 rs3834129 polymorphism has been investigated in several oral cancer populations, but not in Taiwan. This study investigated the role of CASP8 rs3834129 polymorphism on oral risk in Taiwan.

Materials and methods

CASP8 rs3834129 polymorphic genotypes were determined and their associations with oral cancer risk were investigated among 788 patients with oral cancer and 956 age- and gender-matched healthy controls via polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) methodology. In addition, the interaction of CASP8 rs383412

SUBMITTER: Shih LC 

PROVIDER: S-EPMC6689357 | biostudies-literature | 2019 Jul-Aug

REPOSITORIES: biostudies-literature