Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning.

ABSTRACT:

Purpose

To investigate the degree to which lung ventilation and gas exchange are regionally correlated, using the emerging technology of hyperpolarized (HP)-¹²⁹Xe magnetic resonance imaging (MRI).

Methods and materials

Hyperpolarized-¹²⁹Xe MRI studies were performed on 17 institutional review board-approved human subjects, including 13 healthy volunteers, 1 emphysema patient, and 3 non-small cell lung cancer patients imaged before and approximately 11 weeks after radiation therapy (RT). Subjects inhaled 1 L of HP-¹²⁹Xe mixture, followed by the acquisition of interleaved ventilation and gas exchange images, from which maps were obtained of the relative HP-¹²⁹Xe distribution in three states: (1) gaseous, in lung airspaces; (2) dissol

SUBMITTER: Rankine LJ 

PROVIDER: S-EPMC6689416 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature