White matter development in infants at risk for schizophrenia.

ABSTRACT:

Background

Schizophrenia is considered a neurodevelopmental disorder with a pathophysiology that likely begins long before the onset of clinical symptoms. White matter abnormalities have been observed in schizophrenia and we hypothesized that the first 2 years of life is a period in which white matter abnormalities associated with schizophrenia risk may emerge.

Methods

38 infants at high risk for schizophrenia and 202 healthy controls underwent diffusion tensor MRIs after birth and at 1 and 2 years of age. Quantitative tractography was used to determine diffusion properties (fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD)) of 18 white matter tracts and a general linear model was used to analyze group differences at each age.

Results

Adj

SUBMITTER: Ahn SJ 

PROVIDER: S-EPMC6689450 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature