The value of serum metabolomics analysis in predicting the response to cardiac resynchronization therapy.

ABSTRACT:

Objective

To construct a prediction model based on metabolic profiling for predicting the response to cardiac resynchronization therapy (CRT).

Methods

Peripheral venous (PV) and coronary sinus (CS) blood samples were collected from 25 patients with heart failure (HF) at the time of CRT implantation, and PV blood samples were obtained from ten healthy controls. The serum samples were analyzed by liquid chromatography-mass spectrometry (LC-MS). As per the clinical and echocardiographic assessment at the 6-month follow-up, the HF patients were categorized as CRT responders and non-responders.

Results

HF patients had altered serum metabolomic profiles that were significantly different from those of the healthy controls. Differential metabolites were also observed between

SUBMITTER: Zhu MR 

PROVIDER: S-EPMC6689524 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature