Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.

ABSTRACT:

Objectives

To explore the prevalence, risk and genetic characteristics of drug-resistant tuberculosis (TB) from a tertiary care TB hospital in China.

Patients and methods

We carried out a retrospective study including isolates from 189 patients with pulmonary TB at Fuzhou Pulmonary Hospital. All isolates from these patients were subjected to drug susceptibility testing and genotyping. For drug-resistant isolates, DNA sequencing was used to investigate mutations in 12 loci, including katG, inhA, oxyR-ahpC, rpoB, rpsL, rrs ₁ (nucleotides 388-1084 of rrs), embB, tlyA, eis, rrs ₂ (nucleotides 1158-1674 of rrs), gyrA and gyrB.

Results

Among 189 isolates, 28.6% were res

SUBMITTER: Zhao LL 

PROVIDER: S-EPMC6689547 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature