Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model.

ABSTRACT:

Objective

Despite progress in treating relapsing multiple sclerosis (MS), effective inhibition of nonrelapsing progressive MS is an urgent, unmet, clinical need. Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE), provide valuable tools to examine the mechanisms contributing to disease and may be important for developing rational therapeutic approaches for treatment of progressive MS. It has been suggested that myelin oligodendrocyte glycoprotein (MOG) peptide residues 35-55 (MOG^35-55 )-induced EAE in nonobese diabetic (NOD) mice resembles secondary progressive MS. The objective was to determine whether the published data merits such claims.

Methods

Induction and monitoring of EAE in NOD mice and literature review.

Results

It is ev

SUBMITTER: Baker D 

PROVIDER: S-EPMC6689692 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature