Association between vitamin D supplementation and mortality: systematic review and meta-analysis.

ABSTRACT:

Objective

To investigate whether vitamin D supplementation is associated with lower mortality in adults.

Design

Systematic review and meta-analysis of randomised controlled trials.

Data sources

Medline, Embase, and the Cochrane Central Register from their inception to 26 December 2018.

Eligibility criteria for selecting studies

Randomised controlled trials comparing vitamin D supplementation with a placebo or no treatment for mortality were included. Independent data extraction was conducted and study quality assessed. A meta-analysis was carried out by using fixed effects and random effects models to calculate risk ratio of death in the group receiving vitamin D supplementation and the control group.

Main outcome measures

All cause mortality.

Results

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6689821 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature